The first generation: 1978 British experts steptoe and Edowrds customized the world's first test-tube baby, which is a miracle in the history of human medicine. IVF technology is the common name of artificial assisted pregnancy technology such as in vitro fertilization and embryo transfer. It is a comprehensive technology combining embryology, endocrinology, genetics and micromanipulation, and it is the most effective technology to treat infertility. It is to put sperm and eggs in vitro to fertilize the eggs with various techniques, and then move them into the uterus after a few days of culture, so that women can conceive and have children.

Second generation: 1992 Dr. Palermo and Dr. Liu Jiaen of Belgium successfully applied intracytoplasmic sperm injection (ICSI) to human body for the first time, which greatly improved the success rate of IVF technology. ICSI is called the second generation IVF technology by domestic medical circles. ICSI not only improves the success rate, but also greatly expands the technical indications of IVF, which is suitable for male and female infertility. After the invention of the second generation technology, the number of test-tube babies born in the world increased rapidly, and 50 thousand test-tube babies were born in the United States every year.

Third Generation: With the development of molecular biology, in recent years, on the basis of artificial assisted pregnancy and micromanipulation, genetic disease diagnosis (PGD) before embryo implantation has been developed and applied in clinic, so that infertile couples can not only have a baby, but also have a good baby.