"Twinkle Twinkle Star" is a cartoon about growth, friendship and dreams. The story takes place in a beautiful small town. The protagonist Xiao Ming is a little boy who loves music. He has a dream to become a musician. However, his family is not wealthy, and his parents are too busy to make a living and have no time to take into account Xiao Ming's music dream.

Xiao Ming’s good friend Xiao Hua is also a child who loves music. They learned to sing and play piano together in the school’s music class. One day, they picked up a magical glowing star in the forest, which could grant a wish. Xiao Ming and Xiao Hua decided to make a wish, hoping that their music dreams would come true.

A magical thing happened. Xiao Ming and Xiao Hua's musical talents were greatly improved. They began to stand out in various music competitions and won many awards. However, as their fame grew, their relationship changed. Xiaohua became more and more proud, while Xiaoming felt more and more pressure. In the end, in an important music competition, Xiaohua failed because of his pride, and Xiaoming also chose to give up at the critical moment.

After this setback, both Xiao Ming and Xiao Hua realized the importance of friendship and dreams. They decided to put aside their pride and pressure and return to the beautiful town where their dreams originally started. There, they regained their former happiness and innocence, and restarted their love and pursuit of music. In the end, Xiao Ming and Xiao Hua stood on the stage together, moved everyone with their singing, and realized their music dreams.