Brief introduction of needle-free liquid medicine syringe
Needle-free liquid injection syringe can be traced back to 1800, when it was used to treat or improve clinical problems such as neuralgia. Modern development began in the 1930' s, and the technology became more and more mature, which began to play an important role in human clinical treatment, especially in individuals who need to use insulin or growth hormone for a long time after vaccination. This kind of friendly drug delivery method, which is different from needle injection, not only improves the compliance of users, but also increases the opportunity of disease treatment and improvement, and also reduces the waste of medical resources. When administering drugs for infectious diseases, it can also reduce the occupational risk of acupuncture for medical staff, so it is considered to be the focus of the development of medical materials for administration.
This type of syringe can be roughly divided into two types: disposable cartridge injection syringe; DCJIs), and a multi-purpose nozzle injector (multi-purpose nozzle injector; MUNJIs), this kind of mechanical operation mode, mostly uses springs or pressure inert gas as the transmission power source to generate a high-pressure water column for transporting liquid drugs, which makes drug molecules cross the skin barrier at a certain speed and transport them to the living body. Because the skin is the first line of defense against the external environment, especially the epidermis closest to the body surface is very dense, so the speed of drug delivery and the diameter of water column are one of the important indicators of whether it can be delivered to the body through the epidermis. Generally, it is required that the speed of the water column conveying pressure should be greater than 100 m/s and the diameter of the water column should be between 76 and 360 microns before it can pass through the epidermis.
Different transmission power sources have different advantages. The biggest advantage of using spring power is that the equipment is relatively small, durable and low in cost, but it also limits the range and flexibility of power transmission, especially the skin in different parts of the human body has different Young's modulus, so it is necessary to adjust the power transmission accordingly to ensure the effectiveness of drug delivery, and pneumatic power has excellent flexibility. According to the mechanical properties of different parts of the skin, the delivery power can be adjusted to deliver a larger drug volume. If the nozzle injector used for many times is equipped with gas delivery power supply, it can deliver vaccine to up to 65,438+0,000 people per hour, which is proposed by the Centers for Disease Control and Prevention (DCD). If there is a risk of large-scale spread of blood-borne diseases, or a nationwide cold epidemic, or a biochemical attack, it is recommended to use a nozzle syringe that has been used many times for vaccine epidemic prevention.
Needle-free drug delivery device in water column has certain convenience, but there is a considerable gap in acceptance evaluation. Although needle-free syringes are generally considered more comfortable, about 30% users have immediate or delayed pain, redness, burning sensation and bleeding, which leads to limited acceptance of users with long-term injection needs. Therefore, developing a new liquid drug injection mechanism will be a challenge for this type of medical equipment in the future.
GoldMed？ Needle-free liquid drug delivery system-a new type of liquid drug delivery system
The needle-free liquid drug delivery system developed by Huazhan Biomedical Research Institute is different from the general water column drug delivery method. It mainly uses gas-phase molecules composed of conveying power gas (carbon dioxide or nitrogen) and liquid-phase molecules composed of conveying liquid medicine to mix in a medicine conveying pressure tube (Venturi tube), and at the same time atomizes liquid particles, so that the liquid particles are tiny, but enough momentum is generated to penetrate the skin, so the particles are fine, not. In addition to general liquid drug molecules, nano-gold with a particle size below 600nm and hyaluronic acid with a molecular weight below 80kDa can also be transported to the dermis.
In addition, in the experimental model of diabetic wound healing, GoldMed? Delivery of healing promoting formula, the experimental results show that GoldMed? This mode of administration will not only cause further damage to diabetic wounds and hinder healing, but also effectively promote the healing of diabetic wounds due to the deep administration of ingredients in the formula, showing excellent product characteristics.
The New Choice of Gold Beauty Care
In recent years, skin care products have become a luxury trend. Well-known brands use precious gems and minerals to add to skin care products, hoping to form the energy of these precious elements, which can also be used by skin to assist skin care and even delay skin aging. Commonly used materials are crystal, diamond, tourmaline, pearl, amber, malachite and so on. Of course, precious metals are also used, the most common being platinum and gold. The relationship between gold and beauty, concrete evidence can be said by gold wire implantation surgery. The main task of dermis is to be responsible for the tightness and elasticity of skin. In Europe, plastic surgeons bury tiny gold threads in the dermis of skin. Because of foreign body sensation, * * * collagen proliferates, which just makes up for the collagen generation mechanism that decreases with age. With the increase of collagen content, the skin naturally restores firmness and elasticity, and wrinkles will be smoothed, but after all, this is surgery and will be smoothed.
Physical nano-gold particles promote wound healing in diabetic patients.
Physical nano-pure gold particles are a new maintenance partner after medical cosmetic minimally invasive surgery, which makes skin maintenance exercise easier. Tissue engineering experiments show that it can proliferate into fibroblasts, increase collagen production, resist oxidation, and promote the absorption and utilization of effective components, which can not only make skin care get twice the result with half the effort, but also promote the wound healing of diabetes. The results of the wound healing evaluation project conducted by Liang, director of the interdisciplinary research center of medicine and optoelectronics at Fu Jen Catholic University, show that the combined formula of catechin, lipoic acid and physical nano-gold can promote general wound healing and even diabetic wound healing. A wound was made on the back of diabetic rats, and then a formula containing different active ingredients was applied to the wound once a day. After seven days, the wound healing was observed. The results showed that the formula combination containing physical nano-gold obviously promoted the wound healing of diabetic rats. The formula can not only help wound healing through anti-oxidation and anti-inflammation, but also enhance the skin's absorption of active ingredients. Increase the probability of effective components being used by cells, so that this formula combination can achieve the best effect of promoting wound healing on the body surface. Related research has been published in the international journal Nanomedicine 20 12.
Subject: non-invasive, gold