1. Cholera broke out in19th century, with five large-scale outbreaks in history. The outbreak of the disease spread from India to Asia and Europe. At that time, due to limited medical conditions, no effective vaccine was developed, and tens of millions of people died of cholera.

2. As early as BC 1 100 years ago, acute infectious disease smallpox appeared in Egypt and India. Later, smallpox also appeared in different countries at different times, the most serious being in Europe in 17 and 18 centuries. Smallpox spread all over Europe, and the death toll reached nearly 65.438+0.5 billion. Later, smallpox spread to Russia, and the number of people who died of smallpox in Russia was as high as 500 thousand.

3.SARS was discovered in Guangdong, China in 2002, and then spread rapidly to Southeast Asia and even the whole world. This is the latest large-scale infectious disease, when the whole country was in a panic. After more than a year, through many efforts, the disease was gradually controlled and eliminated. During this period, many infected people died and many medical workers were infected and gave their lives.