1 Shennong Materia Medica in the Eastern Han Dynasty mentioned the pure sulfur extraction method, which recorded that people in China invented the pure sulfur extraction method in the 2nd century A.D. ... and it was first discovered in the 2nd century A.D..

The book Bao Puzi in the Eastern Jin Dynasty records: "Take Huachi, Dan, Gai Zengqing and sulfur, steam them in the sand for 50 days and serve them for 100 days." Sulfur has become the only local medicine in the Eastern Jin Dynasty.