Another researcher, Stanley cohen, isolated nerve growth factor from mouse tumor cells while doing the same research. After adding snake venom, he unexpectedly found more NGF activity than mouse tumor cells, and then purified NGF. In later experiments, Stanley cohen experimented with the salivary gland cell extract of newborn mice, but unexpectedly found that the eyelids and teeth of mice were precocious, which explained that the salivary gland cell extract contained growth factors different from NGF, which Stanley cohen called epidermal growth factor EGF for short.
The discovery of EGF won Stanley cohen and rita Levi Montalcini the 1986 Nobel Prize in Physiology and Medicine.
65438-0997 With the support of the State Science and Technology Commission and the Ministry of Health during the Eighth Five-Year Plan and the Ninth Five-Year Plan, Peking Union Medical College and the Institute of Basic Medicine of China Academy of Medical Sciences completed the basic research on the expression of human epidermal growth factor in yeast system, and carried out pilot production and zoological experiments, thus giving birth to epidermal growth factor eye drops. The preparation method of epidermal growth factor has been applied for national patent by China Academy of Medical Sciences.
Due to many factors such as the high market price of EGF, China Academy of Medical Sciences, as the authoritative research and development institution of EGF in China, did not develop EGF into the field of cosmetics at that time.
A discovery that shocked the world, an achievement that won the Nobel Prize, and a fact that skin can change from aging to youth. Since ancient times, all people want their skin to be young forever, but no one can stop the aging of the skin, so they can only try to cover up the aging skin with various cosmetics. People have been looking forward to the appearance of a substance that can prevent skin aging and keep skin young forever ... what is EGF? EGF is a small molecule protein widely existing in human skin cells, and its molecular weight is 62 16 dalton. It is an active polypeptide composed of 53 amino acids, and there are three disulfide bonds in its molecular structure, which determines its biological activity. In human skin, EGF can transmit biological information to cells through phosphorylation of a series of cytokines, enhance glycolysis, activate extracellular synthesis of macromolecules such as hyaluronic acid, activate DNA synthesis, activate RNA transcription and protein synthesis, thus promoting cell proliferation and differentiation and maintaining its growth. At the same time, EGF can also enhance the function of inhibiting apoptosis gene BCL-2, and inhibit external factors (such as ultraviolet rays, low temperature, drugs and hormones) that lead to DNA breakage and variation in cells. Epidermal growth factor is an innate substance in human skin. In infancy, epidermal growth factor is abundant in the skin, which can greatly promote the division and reproduction of epidermal cells. The proportion of newborn cells in skin is much larger than that of aged cells. Therefore, the skin is smooth, delicate, rosy, rich, plump and elastic; With the increase of age, the expression of human growth gene is gradually weakened, the content of EGF in skin is gradually reduced, and the promotion of epidermal cell division and proliferation is gradually reduced. The proportion of newborn cells in the skin is gradually lower than that of aging cells, so the quality of skin declines, and aging phenomena such as pigmentation, wrinkles, dryness and dullness, and decreased elasticity gradually appear. Therefore, the content of EGF in human skin directly determines the skin's youth, so the scientific community regards EGF as a "beauty factor". You can't use EGF if you don't want to be young. Why can EGF rejuvenate your skin? Gene aging of human body leads to cell aging, and cell aging leads to skin aging. It can be seen that as long as gene aging can be reversed, skin aging can also be reversed. After EGF supplementation, the human body can directly promote the expression of skin growth genes, accelerate the differentiation and proliferation of skin cells, increase the proportion of skin newborn cells, slow down the aging of skin cells, and make the skin delicate, shiny, plump and elastic, showing a young state. EGF can improve five functions of skin: 1, remove wrinkles and restore skin elasticity. 2, freckle whitening. 3. Restore ruddy and plump skin. 4. Moisturize the skin. 5. Enhance skin resistance and prevent external stimulation. Physiological research has proved that human skin begins to age after the age of 25. Continuous EGF supplementation can increase the proportion of new cells in skin and reduce the average age of skin. So, with EGF, you don't want to be young.
What is EGF?
Epidermal growth factor (EGF) is a small molecule protein which widely exists in human skin cells. Dr Cohen, an American scientist, found through a large number of scientific experiments that EGF in the human body gradually decreases with the increase of age, and the amount of accounts directly affects the youth of the skin, thus determining the age of the skin. Dr. Fu Cohen won the 1986 Nobel Prize in Physiology and Medicine for this amazing discovery. EGF epidermal growth factor skin care emulsion is a pure biological high-tech skin care product with EGF as the main raw material. EGF is the abbreviation of epidermal growth factor in English, and its Chinese name is epidermal growth factor. EGF is a polypeptide composed of 53 amino acids, which is an inherent active substance in human body. Baby's skin is rich in EGF. With the gradual growth of age, the EGF content in the skin gradually decreases, leading to skin aging. EGF can fundamentally prevent and reverse skin aging and keep skin young. EGF factor is known as "beauty factor", and EGF supplementation is gradually favored by women all over the world.
What is the essential difference between cosmetics containing EGF and traditional cosmetics?
Traditional cosmetics only supplement the external nutrition of the skin and cover the aging skin, but they can't prevent the aging of the skin. EGF epidermal growth factor emulsion can promote the division of skin cells, accelerate the generation of new cells and increase the number of new cells by supplementing EGF in human body, thus gradually replacing skin aging cells, changing skin quality, fundamentally solving skin problems such as wrinkles, spots, dryness and dark yellow caused by EGF deficiency in the body, and making skin young again.
Sheep placenta is popular all over the world. What is the difference between it and EGF epidermal growth factor skin care lotion?
Sheep placenta extract, scientific research shows that sheep placenta extract has cosmetic effect, mainly because it contains a very small amount of animal epidermal growth factor EGF. However, the molecular structure of EGF in animals is very different from that in humans. EGF skin care liquid uses gene technology to produce epidermal growth factor (EGF) which is homologous to human, so it has no rejection, is more easily absorbed by human body, and is safe, reliable and efficient.
Characteristics and Beauty Efficacy of EGF Epidermal Growth Factor Skin Care Emulsion
Features: homologous with human body, transdermal absorption, molecular activation, freeze-drying, and disposable anti-pollution spray bottle.
Efficacy: Smooth wrinkles, shrink pores, dilute pigmentation, improve skin color and moisturize skin.
Efficacy and characteristics of EGF epidermal growth factor skin care lotion at different ages
Over 23 years old: the main function is to prevent the first wrinkle from getting up early, keep the skin moist and beautiful, resist the aging speed, and keep attractive youth and beauty for a longer time.
Age group over 30 years old: the skin moisturizing feeling is obviously enhanced. After continuous use for more than 3 months, wrinkles began to disappear, the skin became beautiful, and the skin remained delicate, returning to the young state of the 20-year-old age group.
Age over 40 years old: The pores thickened due to loose skin begin to shrink, and the skin feels as smooth and delicate as a child when washing your face. After continuous use for more than 3 months, it can smooth fine lines, weaken skin relaxation, eliminate yellow and black, and restore jade-like moisturizing feeling, which is obviously younger than peers.
50 years old and over 60 years old: smooth and delicate skin with increased elasticity. Continuous use for more than 3 months can prevent wrinkles and senile plaques. The most obvious thing is that the skin becomes shiny and rosy, and the face is comfortable, because the eyes are bright and more energetic than their peers.