The role of folic acid is more and more known to us, but most people only know that folic acid supplementation before and during pregnancy is a demand of women. Indeed, whether the baby's embryonic development is normal during pregnancy has a lot to do with folic acid metabolism; One is that the normal metabolic pathway of folic acid is closely related to the production of genetic materials such as DNA; The other is the relationship between normal folic acid metabolic pathway and normal homocysteine metabolic pathway. The metabolic disorder of folic acid will make homocysteine accumulate in the body, forming hyperhomocysteinemia, which will cause various diseases, such as embryonic spina bifida.

Therefore, folic acid is a necessary substance to maintain the normal operation of folic acid metabolism pathway and homocysteine pathway. Normal folic acid metabolism is beneficial to the normal repair function of DNA and other genetic materials in the body, and maintaining the normal level of homocysteine in the body can also avoid many cardiovascular and cerebrovascular diseases such as stroke.

Why supplement folic acid?

If we eat a normal diet, eat a variety of foods and are not picky about food, the folic acid content in food can meet our personal needs. However, in the process of pregnancy, women's demand for folic acid is increasing. In order to meet the normal development of embryos, additional supplements are needed to prevent related diseases.

Another reason is the problem of gene mutation. Mutation of MTHFR gene will reduce the efficiency of transforming folic acid into an active form that can be absorbed by human body. The higher the risk of metabolic disorder of folic acid, the lower the efficiency of transforming folic acid into active form.

Difference between common synthetic folic acid and active folic acid

At present, folicacid, which we often buy in the market, has been invented for decades, with mature technology and stable products. However, recent research has found that its shortcomings have several major effects:

1, if the intake exceeds 200ug/ day, UMFA will be produced, and the accumulation of UMFA will cover up the deficiency of vitamin B 12, leading to misjudgment; These accumulated UMFA are also potentially harmful and will induce cancer.

2. Synthetic folic acid can't effectively supplement folic acid for people with MTHFR gene problems, because it always needs to be transformed into active form through mutated MTHFR, so the general doctor's treatment method is to increase the dosage of synthetic folic acid, which is not only potentially harmful to the body, but also a test of human tolerance.

Therefore, in recent years, active folic acid has gradually appeared in folic acid products. Why is it called active folic acid? Because its structure is very similar to the active form of folic acid needed by human body, it can be directly absorbed by cells without MTHFR transformation.

Compared with synthetic folic acid, active folic acid has more outstanding advantages. Active folic acid has high bioavailability, no UMFA and no upper tolerance limit. Even people with metabolic disorder of folic acid can directly supplement active folic acid.

Difference of active folic acid

There are two main active folic acid raw materials in the market, calcium 5- methyltetrahydrofolate and glucose 5- methyltetrahydrofolate ammonium salt. The latter is the latest active folic acid raw material. Compared with the former, the latter has better bioavailability and curative effect. Uriel? Single leaf? It is a product using 5- methyltetrahydrofolate glucose ammonium salt.