After the Qing Dynasty unified Taiwan Province Province, four trading ports were established, and by the middle of18th century, it was reduced to one in Guangzhou.

Hong Xiuquan, a native of Hua County, Guangdong Province, founded "Worship God" as the predecessor of the Taiping Heavenly Kingdom.

1853, Lin zexu presided over the destruction of more than 2 million Jin of opium shipped to China by foreign businessmen at Humen beach (Humen destroyed opium).

Sun Yat-sen founded the Whampoa Military Academy in Guangzhou Uprising. 1923, China held three meetings in Guangzhou. 1924, the first national congress of the Kuomintang was held, which confirmed the cooperation between the two parties. 1925, the Kuomintang established the National Government and the National Revolutionary Army in Guangzhou. 1926, the national revolutionary army began its northern expedition from Guangdong.