Epidemic febrile diseases is an academic school that gradually emerged in southern China after the late Ming Dynasty, focusing on the study of exogenous fever. During the Ming and Qing dynasties, epidemic febrile diseases were rampant, especially in Jiangsu and Zhejiang provinces, where the climate was hot and fever was prevalent, which objectively prompted doctors to study epidemic febrile diseases and gradually formed a school.

Following the book Plague (1642) written by Wu Youxing at the end of Ming Dynasty and the beginning of Qing Dynasty, the epidemic characteristics and treatment methods are different from those in Treatise on Febrile Diseases, and some related new theories and treatment methods have appeared in Jiangsu and Zhejiang provinces. Their common feature is "epidemic febrile disease is not typhoid", so later people call it "epidemic febrile disease school", and Ye (1667- 1746) is one of the representative figures.

Then came Wu Jutong (1758- 1836), who had no academic views. He comprehensively studied the related theories of Zhang Zhongjing, Wu Youxing and Ye, and linked the transmission of epidemic febrile diseases with the pathogenesis of viscera, and proposed that epidemic febrile diseases can be divided into upper jiao (lung heart) and middle jiao (stomach and spleen).