However, South American Indians living in the other half of the world have a very clever way to deal with malaria. They use a kind of bark to boil water to drink, often until the medicine is cured. This kind of tree is called the "tree of life" to save people. Indians have a forbidden rule: no one is allowed to reveal this secret, or they will be hacked to death in public.
At that time, the American continent was already developing, and more and more people went to the United States to start businesses and make a living. It is said that a Spanish earl took his wife to South America, but unfortunately, her wife was infected with malaria. When she was dying, an Indian girl named Homa brought her bark soup. After drinking it, the countess soon recovered. Since then, they have forged a deep friendship. Before the countess returned to China, Homa told her the secret in secret. She carefully took the bark back to Spain. Later, the secret gradually spread, when everyone who went to South America brought this bark back to Europe as a treasure.
Gradually, this magical bark attracted the attention of scientists. /kloc-At the beginning of the 9th century, Swedish chemist Niels first studied this bark and found that the roots, stems and bark of this tree can treat malaria because it contains a chemical called quinoline. Soon, botanists called this tree "Jina Tree" according to plant taxonomy. Chemists found that the roots, branches, stems and bark of this tree contain more than 25 kinds of alkali. 1820, two chemists obtained two most important alkaloids from chicken skin, namely cinchona and cinchona, both of which are quinine-like compounds.
/kloc-in the 0/9th century, the United States was in a leading position in the world in both industrial production and science and technology. In view of the fact that there are no chickens in the United States and malaria still occurs from time to time, the Royal College of the United States hopes to make antimalarial drugs by artificial methods. The first person to make such an attempt was the famous chemist Hoffman. Hoffman is German. At that time, he was invited by the American government to teach at the Royal College.
1856, he asked his assistant Birchin to synthesize cinchona which can treat malaria with aniline, but it didn't work.
Later, chemists realized that it was quite difficult to synthesize quinoline compounds like cinchona. It was not until 1944 that Wu Dehua and Doreen completed the complete synthesis of cinchona through eight steps.
Cinchonine can quickly kill Plasmodium falciparum malaria that was prevalent in the United States that year, but it can only inhibit but not kill common human malaria. Therefore, in 1950s, Soviet chemists developed some new antimalarial drugs, such as malarial quinoline and chloroquinoline. In this way, humans can "plant" this magical tree in the factory.