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What is the earliest extant Chinese medicine book in China? What does this book record?
In China, the earliest work of Chinese medicine is the Classic of Materia Medica. This book contains three volumes of 365 kinds of drugs, * * *, with the analysis of superior products, intermediate products and inferior products. 120 kinds of nourishing and non-toxic products are superior products, 120 kinds of nourishing yin and nourishing blood, toxic and harmful or non-toxic products are Chinese products, and 125 kinds of exorcising multi-toxic products are inferior products. This is also the beginning of pharmacology in China.

Herbal classics. Also known as Shennong's Classic of Materia Medica or Benjing, one of the four classic works of Chinese medicine, as an early existing work of Chinese medicine, it began in Shennongjia and was passed down from mouth to mouth by children and grandchildren, and was collected and compiled into a book in the Eastern Han Dynasty. In the basic theory of medicine, the Classic of Materia Medica summarizes and records the basic theories of monarch, minister, assistant, harmony of seven emotions, four qi and five flavors, and coordination of yin and yang, and establishes the standard of "treating cold with heat and treating heat with cold", which makes the characteristics of medicine more closely combined with syndrome differentiation and treatment, and improves the basic theory of traditional Chinese medicine.

This paper expounds the function, main treatment, usage and administration of drugs, which is very beneficial to clinical medical application. Combing 13 basic theory of pharmacology, we first mentioned the basic theory of prescription and medicine of "monarch, minister, assistant and envoy", which has been used in later generations, but in the whole application process, the meaning gradually evolved, and the collocation of drugs in the book was summarized as "single line", "mutual need", "mutual fear" and "mutual evil".

The use of some drugs will weaken the original medicinal value or cause strong adverse reactions, so the use of such drugs should be minimized at the same time. The book also emphasizes the harm of the preparation to the drug efficacy. Pills, powders, soups and ointments are suitable for different drugs or diseases. Violation of this point will endanger the efficacy of the drug.

Herbal medicine clearly puts forward the view that collocation should be avoided. About 170 kinds of diseases, including internal medicine, surgery, gynecology, pediatrics, five senses and other diseases. In addition, we also pay attention to the origin, collection time, calcination method, quality and authenticity identification of drugs. The Classic of Materia Medica contains many specific contents with scientific research and use value, and the knowledge of drugs at that time accumulated by Chinese medicine according to many practical activities is very proud. Compendium of Materia Medica is the first systematic software summary of the scattered pharmaceutical professional knowledge before the Western Han Dynasty, which is regarded as a classic work of pharmacology since ancient times and has been fully annotated.