As we all know, systemic lupus erythematosus is an autoimmune disease. With the development of the disease, it will involve many organs and organs in the body in severe cases, and sometimes it will be life-threatening. Therefore, understanding the causes of systemic lupus erythematosus will help us to do a good job in daily prevention. So what? Experts from Beijing Medical Expo will answer your questions. ? Experts explained that systemic lupus erythematosus (SLE) is an autoimmune disease with various clinical manifestations. As long as the cause is related to the following points: 1. Heredity is an important factor in the pathogenesis of lupus erythematosus. People with genetic factors of lupus erythematosus will cause the disease once they encounter induced conditions in certain environments. According to the survey, the proportion of black people and Asians suffering from lupus erythematosus is higher than that of white people. The incidence of family history of lupus erythematosus can be as high as 5% ~ 12%, and the incidence of identical twins is as high as 69%, while fraternal twins are not much different from the same family group. 2. Infection factors: Inclusion bodies and inclusion-like substances were found in glomerular endothelial cells and lesions of SLE patients, and antiviral antibodies in serum increased. Chronic virus (lentivirus) can be isolated from the tissues of NZB/NZW mice, and antibodies against virus-related antigens can be detected in glomeruli. Some people think it is related to streptococcus or mycobacterium tuberculosis infection, but it has not been confirmed in patients. 3. Endocrine factors Endocrine factors mean that if people have endocrine disorders, they may also cause systemic lupus erythematosus. Lupus erythematosus mostly occurs in women of childbearing age, and there is almost no gender difference between children and elderly patients. Lupus erythematosus is common in male patients with testicular hypoplasia, and the hydroxylated products of estrone increase in both men and women. Experts suggest that female lupus erythematosus animal model NZB/NZW mice are more serious than male mice. Androgen therapy can alleviate the disease, while estrogen therapy can aggravate the disease, suggesting that estrogen has an influence on the pathogenesis. Fourth, environmental factors, daily living environment and working environment can be the inducement of systemic lupus erythematosus. This environmental factor includes physical and chemical aspects. Physical factors such as ultraviolet radiation, chemical factors such as drugs, some drugs can cause drug-induced lupus and aggravate lupus erythematosus. The above contents are related introductions made by senior experts from Beijing Medical Museum, hoping to help you.