The samsara of Sanaga means that every generation of Sanaga will create all kinds of life, because following the theory that everything has life and death, all previous generations of Sanaga will perish. However, they will absorb their own creations through artifacts (that is, the kind used to purify the queen, except for a small artifact, which is like a temple) to regenerate the next generation Sanaga (to put it bluntly, they built a reactor part (P and Z) before their death and assembled it with a set of programs (artifacts) to create the next generation). However, the fallen decided to build their own creation (hybrid), so they took control of their master's mind as slaves and spare parts of the hybrid. (by the way, destroy Sarnaga and other creations that try to resist)
The master himself could not resist the arrangement of the creator, but he had foreseen the root of his genocide and decided to stop his fate. This is also the reason why the Queen of Blade was chosen to lead the Zerg (humans were not created by Sanaga, and she had a chance to stop fate). This is the message that Tasada wants to convey to Zeratul, that is, the key to survival is whether the Queen of Blade can get the Zerg out of the control of the fallen again.