In the last five years of the Han Dynasty (BC 183), Cangwu Wangcheng was established in South Vietnam. In the sixth year of Ding Yuan (1 1 1), Cangwu County was established (because there are many Erythrina trees in Wuzhou, also known as Cangwu Flower, the county was named after the flower name). In the fourth year of Tang Wude (AD 62 1), it was originally named Wuzhou. In the sixth year of Chenghua in the Ming Dynasty (1470), Ming Xianzong established the first governor's office in the history of China in Wuzhou, which governed Guangxi and Guangdong, and Wuzhou became the political and military center of Guangdong and Guangxi. Wuzhou was first named in 10 (192 1). Wuzhou municipal government was established in 1927, and Wuzhou is the earliest provincial city in Guangxi. In the early years of Emperor Wu of the Han Dynasty, Guangxin County (under Cangwu County of Jiaozhou) was established in Wuzhou, now Fengkai County of Guangdong Province. Later, Guangxin was called Guangxi in the west and Guangdong in the east, hence the name Guangdong.

It can be said that Wuzhou is the birthplace of Guangdong and Guangxi culture.