For most of the19th century, Owen was the true heir of Zhu Ye Wei. He also agreed with the German naturalist L Okun's "theory of vitality", that is, evolution occurs through the internal dynamics of cells. So when his colleague and friend C Darwin's Origin and Evolution of Species came out in 1859, he expressed firm opposition. He believes that the evolution of natural selection is too rational and is the product of accidental opportunity, so it is unacceptable. He even developed to write an anonymous article (Edinburgh Review, 1860) attacking Darwin, and personally instructed Bishop wilberforce to argue with T. Huxley, Darwin's main defender. When Darwin's works were generally recognized in the scientific community, his attitude also changed, and he acknowledged the accuracy of Darwin's argument. But it cannot fundamentally reverse his position of denying Darwin's theory.