At first, foreign missionaries took power in missionary schools. From the merger of Cai Zhen and other three girls' schools (19 12) to 1927 (16), all the missionary schools were headed by Americans for five terms, among which Pei Desheng had the longest term. (19 16 rpm 1925). Due to the May 4th Movement and the establishment of China during this period, the domestic anti-imperialist struggle situation is rising day by day, which is reflected in the education that is against missionary schools. The Chinese Christian Education Association has to agree that the missionary schools should implement the "new academic system" and the classes with the new academic system, establish their own independent education system, adjust the curriculum and reduce religious courses. Later, the Christian Education Association of China passed "gradually returning the school to the management of China people" and "China people as principals". 1927 (16) In autumn, China people became principals themselves. The first principal of China was Ni (female), a graduate of Hongdao Girls' High School 19 13. During her term of office, Hongdao Girls' School was transferred from three Christian organizations in the United States to two Christian organizations in China, namely, the East China Christian Association and the Shanghai-Zhejiang Baptist Church, and was officially renamed as "Hangzhou Private Hongdao Girls' Middle School". Primary schools and kindergartens are still attached to the middle school department.

Since the autumn of 1929 (18), Zhou Juemei (female) has been the principal. She is the eighth graduate of 19 19 Hongdao Girls' Middle School. Her term of office was the longest before the liberation of Hangzhou. 20 years. After Zhou Juemei became president, the first important thing was to fight for "filing a case" with the education department of the Kuomintang. It was successfully approved in 193 1 (in the 20th year of the Republic of China). Hongdao girls' middle school is budding. During the Anti-Japanese War, Hongdao Girls' Middle School first moved to Jiande, then to Shanghai, and merged with East China 15 Christian School to form "East China United Middle School". Later, he went to Shaoxing to borrow Yueguang Middle School (a missionary school) and co-founded a joint middle school with Jiaxing Xiuzhou Middle School and Hangzhou Huilan Middle School. 1938 (27 years of the Republic of China), Shaoxing fell and Hongdao Girls' Middle School was forced to close.

1945 (34 years of the Republic of China) won the Anti-Japanese War in August, and Hongdao Girls' Middle School returned to Hangzhou to resume school. Although the school building was there at that time, the internal equipment was greatly lost. Books and instruments are gone, only more than 200 tables and chairs, and they are not complete. The number of pianos has dropped sharply from more than 30 to 7. Fortunately, Hongdao Girls' Middle School had a good reputation before the Anti-Japanese War. Many of its alumni are family members of officials, who have considerable status and strength in all financial fields. Out of their love for their alma mater, they all gave generously, and the three groups of the original Christian office also actively sponsored and the Kuomintang government gave subsidies. The school quickly recovered its former appearance. 1946 (35 years of the Republic of China) When the school started in autumn, the number of pianos increased to 17. There is a senior middle school and a junior middle school in the whole school. There are three classes in three grades in high school. In junior high school, there are classes in spring and autumn in grades one and two, and classes A and B in autumn in grade one. The school has more than 300 students and more than 20 teachers (including 5 foreign teachers). Books and harps are everywhere on campus.