I think the most powerful guitarists in anime are Asami Iwasawa, Sonoko, Sara Iwami, Ren Motojo, and Yui Hirasawa.

Hirazawa Yui's "Light Music Girl"

The guitarist and vocalist of the light music department of the private Akiei Women's College initially joined the light music department because he mistook light music for "easy and simple music" . He was a complete beginner in playing the instrument, teaching himself intuitively. He is a confused, reckless, somewhat natural girl who is not good at reading and sports, and has absolute hearing. Additionally, she doesn't gain weight from eating anything, which is the envy of several others in the Light and Sound department.

This man, known as a genius guitarist and Nana’s destined lover, has been an orphan since he was a child, longing to have a family and feel loved. The former bassist of BLAST, now the guitarist and composer of TRANSNEST, is the most popular person of TRANSNEST.

"Feng Xia" by Iwami Sharo

Natsu Feng is a 17-year-old senior student who likes to play the guitar. I am not good at communicating with others because my expressions are not clear and I am often misunderstood. The younger sister of Hedgehog Band Agu. I had seen Hazel Brand on Twitter before he changed schools, but I didn't know his real name or identity. My love for Hazel is hidden in my heart.

Soniko "Super Sonico"

A simple and natural girl learned guitar from her grandmother when she was young because she was interested in rock music. The major at this university is marine biology. Getting out of bed was extremely difficult. Although he is often late, he is still a student bully. As the lead singer and guitarist of the idol group "First Universe Speed".

Asami Iwasawa "Angel Beats!"

Responsible for the lead vocals and rhythm guitar, the quiet band leader. She wasn't the first to bring people together, but her great guitar tones and vocals captivated listeners. In addition, the songs and lyrics played by the band were also written by her. He completely expresses his thoughts through songs and is a girl with a pure musician's soul.

So I think the most powerful guitarists in anime are Asami Iwasawa, Sonoko, Sara Iwami, Ren Motojo, and Yui Hirasawa. The above are all personal opinions.