Yes. Running is a whole-body exercise, and the heart, brain, and lungs all work regularly with the rhythm of running. Listening to music will disrupt the rhythm of running and cause disharmony. Not only will it not exercise the body, but it will damage the body. If the rhythm of the music matches the rhythm of running, it will not have much impact, but it will not have the benefit of letting the brain relax and rest during running. It is best not to listen to music during running. Running with all your heart is the best exercise.