On May 27, 2006, the single "U" was broadcast for the first time on M! Countdown. Kyuhyun debuted as a transfer member of the singing group Super Junior and became the 13th member of the group; in November On the 5th, he joined the sub-group Super Junior-K.R.Y. and sang the theme song "Only for One" for "Hyena".
In April 2008, he joined the sub-group Super Junior-M and released the first regular Mandarin album "Mystery".
On March 12, 2009, the third Korean regular album "Sorry, Sorry" was released; on May 2, the first Mandarin mini album "Super Girl" was released; on May 14, the The third official Korean reissue album "It's You"; on June 24, he sang the OST song "Dream Hero" for the TV series "Partner" with Yesung and Ryeowook; on December 10, he made his debut with "Sorry, Sorry" Won the Korean Golden Disc Award.
Since 2011, he has been the regular host of the Korean variety show "Radio Star"; on March 15, he sang the theme song "Hope is a dream that never sleeps" for the TV series "Bread King Kim Tak-gu" ; On April 8, he starred in the musical "The Three Musketeers" held at the Gwangju Culture and Art Center Grand Theater; From August to September, he participated in the Korean singing program "Immortal Songs 2"; On August 2, the fifth Korean regular album was released Album "Mr. Simple"; on September 19th, the fifth regular Korean reprint album "A-CHa" was released; on November 26th, he joined S.M THE BALLAD and released his first album "Miss You Very Much"; on December 30th, Won the MC category special award at the MBC Entertainment Awards.
On January 19, 2012, he won the Seoul Music Awards for the first time with "Mr. Simple"; on May 9, the third Japanese single album "Opera" was released; on July 4, it was released The sixth regular Korean album "Sexy, Free & Single"; on August 29th, sang the theme songs "SKY" and "To the Beautiful You" for the SBS TV series "To the Beautiful You"; on December 30th, won the MBC Entertainment Award Grand Prize Newcomer Award.
On January 7, 2013, the second regular Mandarin album "Break Down" was released. On January 15, he won the Korean Golden Record Award for "Sexy, Free & Single", which was the third time he won the Golden Record Award after "Sorry, Sorry" and "Mr. Simple"; on January 23, Super Junior -K.R.Y.'s first Japanese single album "Promise You" was released; in May, he and Luna sang the Korean version of the theme song "Shine Your Way" for the cartoon "The Croods"; from May 19 to October 27, he served as KBS Variety show "Mamma Mia!" "Fixed host; on June 10th, guest appearance in Henry's album MV "Trap"; on December 11th, the fifth Japanese single album "Blue World" was released.
In January 2014, he starred in the musical "Moon Embracing the Sun"; on March 21, the third mini album "Swing" was released; in June, he starred in the musical "Rain in the Rain"; in September On the 1st, Super Junior released its seventh regular album "Mamacita"; on November 13th, it released its first solo mini-album "In Gwanghwamun", which included "My thoughts, Your memories" composed by Kyuhyun; on November 28th , held his first solo mini-concert; on December 30, he won the MBC Entertainment Awards Music Talk Show Excellence Award.
In January 2015, he starred in the musical "Robin Hood"; on March 10, he sang the theme song "Until I Arrive at Your Planet" for the TV series "Hao Jiu's Love"; on April 7, Li Wenshi The collaboration song "She's Coming" with Kyuhyun was released and included in Lee Moon-se's 15th regular album "New Direction". This is the first time Lee Moon-se has sung a song with other singers in 16 years; on April 10, Kyuhyun appeared in The South Korean KBS variety show "Plop Plop India" premiered; on June 27, the theme song "The Time We Loved" was sung for the TV series "The Time I Loved You, 7000 Days"; on July 16, Super Junior released a special 10th anniversary album "Devil"; on August 5, Super Junior-K.R.Y.'s second Japanese single album "Join Hands" was released; on August 20, he served as a judge on the Korean music program "Super Star K7"; on October 15, the second Japanese single album "Join Hands" was released; The second solo mini album "Autumn is Coming Again", with "Millions of Pieces" as the title song; on October 18th and 25th, he participated in the Korean singing program "The King of Masked Singer", singing covers of the songs "Trance Confession" and "Foreign Land" People" and "Wild Flowers"; on November 3, the digital single "The Days Gone" was released; from November 5 to 15, seven solo concerts were held in Seoul; in November, he starred in the musical "Werther".
On January 20, 2016, he won the Sound Source Award at the Golden Disk Awards for his album "At Gwanghwamun"; from April to May, he held 12 solo concert tours in Japan; in the same year, For the first time, he set foot in the field of TV dramas, starring in the web drama "The Woman Who Will Die When You Fall in Love".