Although X chromosome is regarded as a symbol of femininity, motherhood and femininity in folk discourse system and imagination, the more X chromosomes in cells, the better. Because Barbie got several extra X chromosomes from her parents at the beginning of her life, these extra X chromosomes, like guerrillas, interfered with the organ development in the embryonic period and affected the corresponding functions of the human body during the embryonic development. In childhood, the behavior of beautiful women is basically the same as that of normal people, but they are slightly mentally retarded, which may be one of the reasons why people say that "beautiful women are stupid".

Once they enter puberty, with the maturity of sexual development, they will obviously show symptoms of menstrual disorder, which will affect their fertility because of low ovarian function. The more X, the worse their fertility. However, the doctor pointed out that although Barbie's intelligence cannot be recovered through treatment, as long as she treats menstrual disorders and improves ovarian function, she still has hope to give birth to the next generation.

Some patients are also accompanied by schizophrenia and have delusions of victimization. Depression and reticence make it very difficult to make friends.

Zheng Lixin specially reminded that because these patients are prone to give birth to children with abnormal number of fertile chromosomes, prenatal diagnosis must be carried out once they are pregnant, otherwise the pain will be passed on to the second generation.