it's my father who has this disease. My dad is a veterinarian. He got prurigo nodosa before the summer of 212. Of course, he didn't know it at first. He always thought that mosquito bites caused local infection. Based on his own medication experience, he used antibiotics and hormone drugs for external use. Not only did it not work, but it was also infected from one leg to the other as time went on. The word infection is not accurate. The disease does not infect others, but only the body.
I didn't tell you until my dad's prurigo festered and the wound was connected, which made his tortured face old. I was a graduate student in Shanghai at that time. I remember that my first cloned sheep was just pregnant and I was in high spirits that modern medicine could do anything. I think it's his own fault that the skin disease has reached such a serious level. I first criticized my dad, saying that he didn't go to a big hospital to take drugs without authorization and didn't cherish his health, and then forced my dad to go to the most formal dermatology hospital in the city (not the county).
The doctor diagnosed prurigo nodosa as soon as he saw it, and asked my dad if he needed any laboratory tests (in fact, microscopic identification). My dad did the same and was diagnosed again. I got back a bunch of hormone oral drugs, which I don't shy away from. It is a recognized dermatology hospital in Xuzhou, and the medication scheme is also authoritative. I take antihistamines orally. But as my dad expected, except for the side effects, it can be said that it has no effect! He stopped taking the medicine privately.
at this time, my dad's face is allergic easily, so he has no choice but to avoid eating. He is afraid to eat good fish and vegetables, and his life is boring. At that time, he told me that some diseases only find the upper body when they live to a certain age, and when they get on the body, they only increase as old as they are, and they can only be brought into the coffin.
My father is only in his early fifties, and he is usually very optimistic. He has been through all kinds of storms in his life, but he was defeated by an inexplicable skin disease. It grieves our whole family to see him so negative.
I am very dissatisfied. I am not satisfied with the prescriptions prescribed by authoritative dermatologists. I am defeated by this small skin disease!
So I checked the information about prurigo nodosa. If you are a patient or a family member, you must know how disappointed I am. The first sentence of the official description of prurigo nodosa in medicine is: the cause is not clear! The last sentence is generally: endocrine dysfunction may also be related to this disease. (Not yet clear! It may be related! )
I'll hold back my anger and not swear. We know that human beings can fully overcome diseases whose etiology is not clear, even the characteristics of pathogens are unknown. The etiology and pharmacy are sometimes two different things, such as smallpox and anthrax. As early as decades ago, human beings eliminated these virulent viruses through toxicity attenuation and immunoglobulin injection prevention, but now they know very little about these viruses themselves.
So, is there any specific treatment plan and medicine for prurigo nodosa in the medical field? Yes, it's my dad's plan to go to a specialized hospital for dermatology, including topical corticosteroid cream, oral antihistamines, and finally physical therapy, such as surgical resection (who dares to try this method? Bone curettage? How big is the noodles? ）。
With the development of medicine and biochemical molecular medicine, we can now clone and improve animal genes (pharmaceutical transgenic sheep), extract special proteins from the breast milk of cloned sheep's offspring through genetic modification of sheep, and make them into specific drugs for human use. What a complicated pharmaceutical chain, but facing a skin disease, we don't even understand its pathology, and medication is even more nonsense. Is it impossible for anyone to do it or really can't do it?
I doubt it: nobody did it.
my suspicion is groundless, just suspicious. I searched for medical college papers in the discussion library. Some used injection therapy, and some used traditional Chinese medicine therapy, but these methods were not used at all in big hospitals in reality, which showed that either the papers were moist or the cure rate was not absolute, so they could not be popularized. Most of the patients said that it was caused by mosquito bites, so the disease was mostly caused by barefoot workers in the countryside, and it was not contagious and immortal, and it did not delay work and life in the early stage. Therefore, I suspect that no medical team has ever conquered it, and scientific research needs funds. The scientific research team gives priority to the study of fatal diseases and rich diseases, which is a secret known all over the world because of its high returns.
The conclusion must be based on sufficient facts. I admit that my suspicion is unfounded. But I have to continue to doubt. What if my suspicion is wrong? Once, a group of people in a certain country took a little research funding to study this disease, but they didn't understand it? It doesn't mean anything to me. So I'd rather my suspicions were correct.
to treat my father, I decided to start from scratch and explore for myself.
through detailed communication with my dad, I learned that this disease was caused by a lot of mosquito bites on the tibia of the right calf after I was too sleepy when I was on duty in the farm at night in June 212, and I drank some wine during the day. Once I fell asleep, I felt extremely itchy and scratched many times, which caused the wound to connect, and my blood was blurred. At first, my calf was close to the ankle and tibia, and then it moved upward like a tent, which hardened and itched, expanding and increasing. He said that after getting sick, he met several patients, and the incidence was similar.
I re-indexed the pathological data and found that there are two kinds of pathological analysis. The first one:
"The cause of prurigo nodosa has not been clarified, and some patients get sick after being bitten by mosquitoes, bedbugs or other insects, which may also be related to gastrointestinal dysfunction and endocrine disorders."
second, the analysis of TCM theory, as follows:
"Damp evil is sticky and stagnant, stagnation turns into heat for a long time, damp heat accumulates in the vein of muscle, damp heat bets, qi stagnation and blood stasis, obstruction of meridians and collaterals, and obstinate dampness coalesces."
I once believed in this five-dimensional theory of TCM and was infatuated with it. I can only say that you are lucky to be symptomatic. I can only look forward to the miracle of Chinese medicine. Of course, as a student in the laboratory all day, I don't have much medical knowledge and clinical cases, so I'm not qualified to say this, but if I decide to explore for myself, I dare to say anything to myself. I won't take the road of traditional Chinese medicine.
At the end of 215, with the successful completion of the project of genetically modified cloned sheep, I applied to study PhD in France. In May of the following year, I received several offer, one of which was related to the disease of human beings and animals by the famous Baxx Institute in France. My undergraduate major is animal experiment, which is actually a clinical veterinarian. I have seen all the animals, big and small, and most of them are mice. Graduate students do high-end animal-derived protein gene cloning, so it is not surprising to receive the invitation of such a topic. However, after reading the institute and the introduction of the topic, I suddenly remembered that prurigo nodosa is almost caused by mosquito bites, and a thought flashed. Could this be that people and animals are sick?
It sounds strange that people and animals are sick. In fact, human beings have seen many kinds. Rabies is, AIDS is, and so is the Black Death, which once lost more than half of the population in Europe. Except for fatal diseases, those non-fatal diseases are gradually paid attention to now, so more topics have been put forward. If so, it explains why the current data can't even explain the pathology, and it also opens a door. Perhaps, the disease is very simple, or perhaps, like AIDS, the pathogen comes from animals or insects, but it can't be cured if it invades the human body.
Originally, most international students would do lucrative projects. Some students went to study the topic of new drugs for cancer. I asked him if your topic can treat cancer. He said no, but as long as there is a little use, new drugs will be approved quickly and generate rich returns. There are also a small number of students studying abroad who insist on their own ideals and subject direction and serve the country through scientific research. And I, because of my dad's skin disease, finally chose a relatively unpopular topic in today's era. This is fate. There are many roads, but there is only one father. There is no right or wrong choice, just don't regret it.
I trained in French for two months after graduation, and flew to the western hemisphere at the end of September 216.
next, I can't tell you all about what I did in the institute. I'll just describe it briefly. I usually do projects and go to the library during my breaks. The library has a large number of research papers and historical yearbooks. The more you read the history, the more you admire the institute. You can imagine how bold and wise it was to treat people bitten by mad dogs at first, and the dedication of scientific researchers: a person who was bitten by a mad dog for dozens of places came to the institute to find a scientist for his life. At that time, the scientists were faced with two choices, not saving, because there was no mature theory and medicine for rabies (mad dog disease) at that time, and they could refuse. After refusing, this person has two ways to die, one is to be scalded to death (at that time, it was popular in France to fight poison with fire, that is, to insert a red-hot shovel into the wound), or to die of rabies one day after 1 days; Save, treat the living as mice and do human experiments, which is not allowed by law and ethics. In the end, in order to save people, scientists have put honor and personal safety aside, relying on the theory of microbiology hypothesis to collect the saliva of mad dog to make dry bacteria, and collect the spinal cord of mad dog to make dry powder, during which they will be infected with rabies if they are not careful (it was called mad dog disease at that time, and there was no effective disinfection method and mature isolation equipment). The invention of rabies and vaccine can't be separated from these selfless scientific researchers. On the other hand, if it weren't for the tight time and strong sense of mission, there wouldn't be such a bold attempt. On the other hand, now, the scholars of our generation, whether they are doctors or postdocs, are doing projects slowly, and all with the help of instruments, the paper data is the result we care about, because illness and death are not in front of us for us to choose.
A sense of mission is a good thing. I unconsciously read most of the yearbook materials about the illness of man and beast. I have a strong intuition that the type of prurigo nodosa is just an ordinary superficial fungal arboreal disease, but there is no special subject for this fungus, so there is no specific medicine yet. If you know the invasion preference of fungi, you will understand that the statistical laws of patients with a certain skin disease, such as low immune system, high or low blood pressure and moisture in the body, are not the cause, and the quality of dermal cells is not the cause. The theory of meridian stagnation can be attributed to the immune system, which is not the cause. If the immune system is slightly low, people with low immune system should get countless diseases, feel a risk, and if they lose love, they will die of all diseases. On the contrary, young people and even athletes can get prurigo.
when I have time, I video with my dad. My dad's prurigo is getting worse and worse, but fortunately, it has not broken out all over the body and has been concentrated in the calf. When he realized that I had something to do with his pruritus when I chose my subject, he was very angry. He was afraid that I would go the wrong way and said that I couldn't afford a house in the future if I worked in an unpopular job. I explained to him in time that this was not the case, and also told him about the discoveries of rabies vaccine and other lifesaving in history, which not only saved people but also paid off.
I have made friends with some students on other topics intentionally or unintentionally in the library. I often ask them questions. In fact, whoever puts down his posture first will be appreciated by the other party and let go of his guard. Sometimes the communication between people is very simple. Our ancestors told us to study with an open mind, and it is always good for a threesome to have a teacher. I also make friends because they have more places that can help me in the future.
I went back to China during the Christmas break at the end of the year, and brought a little sample of prurigo and dandruff.
Soon, I felt that the conditions were basically met (in fact, I couldn't wait), so I got my friends to tell me about my dad and my guess, and they were all willing to help me. Teamwork is much stronger than one person in terms of instrument use, time allocation and their respective professional theories. On weekends, European students basically go back for the weekend, and only students from China and other developing countries are left in the laboratory. It is normal for us to add an extra class. At this time, you can actually do your own thing. We classified the characteristics of more than 2 kinds of known mycoses, and then cultured them in the laboratory with the samples I brought specially after Christmas (prurigo nodosa sampling). After 4 weeks, they were locked by electric microscope, but the results were vague and filtered by ultraviolet rays. After everyone's discussion, the students of molecular biology think that this fungus is not easy to cultivate, and the error is too big, which can only narrow the locking range, and it may be an unknown fungus.
In any case, I narrowed down the scope of locking. Finally, I decided to make a bold drug attempt directly. At first, they thought this method was too unscientific and equal to illegal human trials. But in the end, they all supported me after I told them about the pain of the disease, the helplessness of the medical community and the safety of the trial. Because we don't have enough samples, and we don't have the experimental authority, besides, if the fungus of prurigo nodosa is not in the list of known fungi, there are tens of thousands of unknown fungi that need to be cultivated or eliminated, and it may not be clear what kind of fungi it is until graduation.
Speaking of human trials, in fact, there are many Chinese medicine clinics run by China people in Europe, which are private. Some diseases don't have specific western medicine, and white people also go to Chinese medicine clinics to use Chinese medicine, and some of them are really effective, and there are queues. No matter Chinese medicine or western medicine, most of us become clinical trials passively or unintentionally when we enter the hospital. This is an unavoidable fact. If there is no clinical trial doctor, where can we get the experience? In addition, Europeans will also use folk remedies, have no way out or lose trust in hospitals, and they will try both Chinese medicine practitioners and witch doctors, which is also a spirit of exploration.
My dad is a very bold man. He used to treat himself with liquid nitrogen. He poured liquid nitrogen at minus 196 degrees into the affected area, trying to freeze the diseased tissue to death. Under the frozen state of pathogenic bacteria (he always thought that pathogenic fungi existed), he fell off with the diseased tissue cells, and then washed the affected area with concentrated solution to kill the residual pathogenic fungi and the remaining diseased cells.
My eyes are blurred at the thought of this. Although this whimsical method won't kill me, my dad really doesn't want to live to do it! When I was young, I had liquid nitrogen at home. My dad made a special experiment to show me that liquid nitrogen was dangerous. When he poured white smoke on the toad, it stopped moving. When the white smoke dispersed, his body turned white, and then it was hard. When he knocked on his leg, his leg was broken, like an ice sculpture ... Treated with liquid nitrogen, my dad secretly did it alone!
So with such a bold father, drug testing is nothing at all.
After being "frozen" by liquid nitrogen, the right leg adhesion wound recovered soon after prurigo fell asleep.
I am not qualified for medicine and pharmacy, and neither are the graduate students who helped me privately, but my father believed me and said that he would use it for me if he had new ideas.
In fact, the experimental drugs are not so advanced, and it is even easier to have the help of students in molecular biology. Many basic drugs and preparations are ready-made, and they are only used for fungi with different characteristics, but they must have pharmacological and chemical knowledge in dispensing, otherwise they will make a pile of flocculent reactants, and the reactants may still be toxic. My dad encouraged me to say that folk remedies have not been tested by mice, so everyone dares to try. You have read so many books, so what am I afraid of?
Actually, superficial fungi are all external drugs, and I dare not give them to my father without 1, mice.
Later, maybe it was luck, or maybe I was in the right direction. One weekend in early summer, my dad gave me good news, saying that it stopped itching after a week of rubbing, but it stopped itching!