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When is the substantive thawing of Sino-US relations?
That was at 1972,

1972 On February 2 1, US President Nixon left for China on the presidential plane "Spirit of 76" for a seven-day historic visit. In the afternoon, Mao Zedong met with Nixon in Zhongnanhai. The two sides held historic talks and outlined the blueprint for Sino-US cooperation. Zhou Enlai and Nixon also held several talks successively, and the leaders of the two sides had a frank and in-depth exchange of views on international issues and bilateral relations of common concern. On February 27, China and the United States reached an agreement on the joint communique in Shanghai, which was published on February 28, marking a new stage of Sino-US dialogue and cooperation. The Sino-US Shanghai Communiqué is a turning point in Sino-US relations from conflict confrontation to peaceful cooperation since 1949. Its publication was a historic breakthrough and milestone in Sino-US relations after the founding of New China. The American policy of containment and isolation against China came to an end, which laid the foundation for the normalization and further development of Sino-US relations in the future.