The prefrontal cortex is the part of the human brain that matures slowest and declines fastest in old age. The prefrontal cortex, located in the front of the brain, is an important area of advanced cognition, emotion and social behavior. It also plays a key role in attention, decision-making and planning. However, it takes a long time for the prefrontal cortex to mature, and it will not mature until the twenties. With the increase of age, the prefrontal cortex is also one of the most fragile brain regions, which may lead to problems such as memory decline, decision-making ability decline, and social ability decline.