1909, Danish botanist and geneticist Johnson called a subtle factor that determines and controls biological inheritance and variation "gene". He thinks the concept of "genetic factor" in Mendel's hypothesis is inconvenient to use. "Gene" means the most basic factor and can better reflect the essence of things than "genetic factor". But at that time, scientists could not really understand what a "gene" was, nor could they see this mysterious little thing with their own eyes.