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What diseases have there been since ancient times, large-scale infectious diseases: such as plague and anthrax. It better be both.
Cholera (a serious intestinal infectious disease, one of the two Class A infectious diseases).

Plague (natural focus disease caused by Yersinia pestis, also known as the Black Death).

Smallpox (a highly contagious acute severe eruptive disease caused by virus infection, and the first infectious disease that has been eliminated by human beings in the world so far).

Tuberculosis (pulmonary infectious disease caused by Mycobacterium tuberculosis, commonly known as "consumption", which seriously threatens human health).

Infectious atypical pneumonia (SARS) is a new respiratory infectious disease caused by SARS coronavirus infection.

Anthrax (acute infectious disease caused by Bacillus anthracis).

People are infected with highly pathogenic avian influenza (acute respiratory infectious diseases caused by some strains of certain subtypes of avian influenza A virus, such as H5N 1 and H7N7).

Measles is an acute respiratory infectious disease caused by measles virus.

Bacillary dysentery (referred to as bacillary dysentery, a common acute intestinal infectious disease caused by Shigella dysenteriae, and amebic dysentery are all legal Class B infectious diseases in China).

Schistosomiasis is a parasitic disease that seriously harms human health.

Malaria (called miasma in ancient China, caused by the bite of female Anopheles and the introduction of parasitic plasmodium into human body).

Dengue fever is an acute infectious disease caused by dengue virus and spread by mosquitoes.

Others include epidemic hemorrhagic fever, whooping cough, leptospirosis, Japanese encephalitis, brucellosis, rabies, diphtheria, polio, influenza A (H 1N 1), typhoid and paratyphoid, AIDS, gonorrhea and syphilis. Among them, AIDS is a bad infectious disease that has not been conquered so far.