The great plague at the end of the Eastern Han Dynasty was the biggest plague in the history of China. Although it has not spread to the whole country, most parts of China, especially the north, basically live in the shadow of the epidemic. As for the number of deaths caused by the plague, it is recorded that it is 50 million and 20 million. Although there is no unified statement so far, it is certain that the death toll is tens of millions, which is undoubtedly the most terrible epidemic in China's history and ranks among the major plagues in the world. At that time, the plague was called typhoid fever, which was different from today's typhoid fever. At that time, "typhoid fever" refers to all exogenous diseases, such as cholera, dysentery, pneumonia, influenza and so on, which are highly contagious. In other words, there was probably more than one infectious disease at that time, but many infectious diseases were raging at the same time.