The study of animal embryonic development chemistry originated from J. Loeb's physical and chemical analysis of sea urchin fertilization and parthenogenesis. Chemical embryology, written by Joseph Needham 193 1, systematically expounded the research objects and methods of chemical embryology, summarized a large number of materials about the chemical composition, nutrition and metabolism of embryos, and established a preliminary discipline system, but the main contents were mostly limited to the chemical aspects of embryonic development.