From 1900 to 1902, Austrian doctor K. landsteiner and other scientists will not cross-mix with human serum and red blood cells. By observing the cell agglutination reaction, two kinds of human red blood cell allogenic antigens A and B were detected for the first time. 1924 F. Bernstein proved that ABO blood group is controlled by three multiple alleles respectively, which is the first discovered human blood group genetic system. Since then, a variety of red blood cell antigens have been found in some animals and humans (see blood group inheritance), and their genetic rules have gradually become clear. 1958 French immunologist J. Dorset discovered the first human leukocyte antigen. From 65438 to 0959, Australian immunologist F.M. Burnett put forward the theory of clonal selection, which explained the source of antibody diversity at the cellular level. The development of molecular genetics and somatic genetics in 1970s further promoted the development of immunogenetics. For example, genetic engineering and molecular hybridization techniques have proved that the heavy chain and light chain of antibody molecules are encoded by several DNA sequences respectively; The technique of preparing monoclonal antibodies was created by somatic hybridization. These new developments make the study of immunogenetics an important part of molecular genetics.