The development of TCM can be roughly divided into three stages:
1. The first stage is from 1958 to 1978. Relying on the connotation development, Huabei Pharmaceutical Factory made great efforts to reform and optimize the technological conditions of strain breeding, fermentation and refining by pioneering and innovating, digesting and introducing technology, so that the production level of antibiotics entered the international advanced ranks at that time. The total number of products increased from 5 when the factory was established to 75, and the total annual output of antibiotics increased by nearly 20 times, which initially laid the advantages of scale and cost. North China Pharmaceutical Factory built oxytetracycline and propyne solvent workshops in 1958 and 1959, and built a workshop for extracting vitamin B 12 from streptomycin waste liquid. 1969 tetracycline workshop was built in oxytetracycline factory. 1970 in may, the kinescope was successfully trial-produced in the large bottle workshop of the glass factory. 1February, 1975, Huabei Pharmaceutical Factory was established. In June, 198 1 year, it was placed under the provincial electronic bureau and became Shijiazhuang CRT Factory (later Shijiazhuang Gemstone Electronics Group Company). 1973, the comprehensive workshop of anticancer drugs was started, and lincomycin was produced on 1979 after completion. 1970 the central laboratory of north China pharmaceutical factory was reorganized into an antibiotic research institute. The new antibiotics developed and put into production by the Institute of Antibiotics over the years include: bacitracin, norvancomycin, neomycin, mucomycin, kasugamycin, Zheng Guang mycin, gibberellin, Gengmycin, Zhengding mycin, Lincomycin, Lushan mycin, Pingyangmycin, clindamycin hydrochloride, cephalosporin C and so on.
2. The second stage of TCM development is from 1979 to 1990. At this stage, the key point is to transform enterprises, implement business contracting, implement modern management, conduct horizontal joint and technology transfer, and gradually strengthen the introduction of advanced technology and equipment. The variety of products increased to 98, and the ratio of total antibiotic production 1978 increased by 54%. 198 1 year, the total quality management office was established in north China pharmaceutical factory (1983 was changed to enterprise management office), and the total quality management was introduced and popularized, and the quality of enterprises was continuously improved. 1986 won the national quality management award, 1987 was promoted to the national second-class enterprise, and 1989 was promoted to the national first-class enterprise. Among the 26 main products of Huabei brand, 2 were awarded by the Ministry of Chemical Industry, 8 by the State Administration of Traditional Chinese Medicine, and 23 by the title of provincial quality products (including 7 by bureau-level excellent products). The five major products have successively won three national quality awards and silver awards. Since 198 1, Huayao has gradually developed a cross-regional and cross-industry horizontal economic alliance. By the end of 1990, there were 25 close joint ventures. The accumulated investment of 25 close joint ventures reached 53.6 million yuan. 1982 65438+February, North China Pharmaceutical Factory built the second penicillin production line, and the penicillin production capacity doubled.
3. From 199 1, TCM entered the third development stage. During this period, Huayao actively adapted to the new situation of market economy, deepened enterprise reform, changed operating mechanism, intensified technical transformation and infrastructure construction, expanded enterprise scale through external introduction and internal connection, and made great progress in production, operation and various undertakings. By 1997, the total output value, sales revenue and realized profits and taxes of Chinese medicine industry increased by 326%, 422% and 16 1% respectively, and the cumulative number of products increased to more than 300. 1991March 10, North China Pharmaceutical Group was established, and was later listed as one of the first 55 pilot groups in the State Council, and obtained the right to import and export foreign trade and foreign affairs examination and approval, and successively established a finance company and a new drug research and development center. 1992 10, Huabei pharmaceutical factory reformed the production and operation part of the joint-stock system, and established Huabei pharmaceutical co., ltd after directional fundraising. 1993 North China Pharmaceutical Co., Ltd. went public, 1994 Huayang Pharmaceutical Co., Ltd. went public on the Shanghai Stock Exchange, becoming one of the first listed companies in Hebei Province. 1995 and 1997, Huayang Pharmaceutical increased its capital and issued shares twice. Huayao Co., Ltd. raised social funds of 700 million yuan through directional raising, social raising and two capital increase and share allotment. All these funds were used for technical transformation, infrastructure and new product development projects during the Eighth Five-Year Plan and the Ninth Five-Year Plan, which kept these projects at a high speed, high quality and high level. From 65438 to 0992, Huayao began to use foreign capital. Sixteen Sino-foreign joint ventures and cooperation companies were established in six years, and a compensation trade project was completed, with a total utilization of foreign capital of 70 million US dollars. According to the needs of enterprise development strategy, Huayao implemented asset reorganization, successively acquired and merged 12 enterprise and leased two enterprises, thus expanding its scale and strength. 1996 1, Huabei pharmaceutical factory was reorganized into a wholly state-owned company-Huabei pharmaceutical group co., ltd.