If the Persian Empire wanted China, it would enter Central Asia, and then enter China at that time through Xinjiang and Hexi Corridor. However, at that time, the ethnic tribes in the grasslands of Central Asia were extremely strong, and the expansion of the Persian Empire to the north and northeast was always difficult. Ju Lushi, the founder of the Persian Empire, died in the Central Asian War. So Persia was forced to adjust its expansion direction and expand westward.
There was a strong and unified Xiongnu between Persia and China, and then there was the Guishuang Empire. Basically geographically isolated from Persia and China. It is difficult for the two sides to have direct collisions and conflicts.
Extended data
Not to mention that Persia and Alexandria only reached India. In fact, China's main threat in history came from the north, not the west.
This is determined by geographical reasons. Western China and the Himalayas are now a natural barrier. Coming here is like going to heaven. Further north, it is a desert wasteland in Central Asia. Under the conditions at that time, large troops had to pass through such a place, and the logistics support could never keep up. How to transport grain and grass materials?
And that time should be the Spring and Autumn Period and the Warring States Period in China, and the north was occupied by the powerful Xiongnu. Even if we walk out of the desert Gobi in Central Asia today, the first thing we face is not China, but Xiongnu. Therefore, influenced by geographical factors and its own factors, it was difficult for ancient Persia to reach China and China at that time.