In the second year of Zhangwu (AD 222), Liu Bei retaliated against Wu Dong for Jingzhou to protect Guan Yu, and was burned by Wu Jun, and was defeated. Liu Bei felt ashamed to return to Chengdu, the capital, so he had to live in Baidicheng and renamed the inn "Yong 'an Palace". People who live in the name of "security" don't get security. It was in this Yong 'an Palace that Liu Bei became ill and his condition gradually worsened until Zhang Wu died in April of the third year. Kong Ming led officials back to Chengdu from Zigong. Liu Yuxin Chen went out to meet the coffin and settled down in the main hall. After the mourning ceremony, read the testamentary edict. Zhao said: "I started to get sick, but I had diarrhea;" After becoming a miscellaneous disease, I don't know what I can do. " "Diarrhea" means diarrhea, which is the medical term of Han Dynasty.

From June of the second year of Zhangwu to April of the third year of Zhangwu, Liu Bei's "diarrhea" lasted for nearly a year. Therefore, it cannot be inferred from pathology that Liu Bei's "diarrhea" is this disease. If it is a general gastrointestinal dysfunction, although medicine was underdeveloped at that time, Liu Bei was in office and the medical and health care conditions were quite good. This disease can't be cured badly, so the biggest possibility of metaplasia is a chronic diarrhea that is difficult to control, that is, cancer diarrhea. Most cancers that can cause diarrhea are in the lower digestive tract, so the biggest suspect is "colorectal cancer".